But, well, I never met a book meme I could resist, so here you go. I make no claims to this list's legitimacy as a canon or source for reading recommendations. Bold if you've read, italicize ones you fully intend to read, underline if it's a book/series you've read part but not all of.
1. The Lord Of The Rings Trilogy, by J.R.R. Tolkien - although I don't love this as much as many people do. In fact, I actually prefer the movies.
2. The Hitchhiker's Guide To The Galaxy, by Douglas Adams
3. Ender's Game, by Orson Scott Card
4. The Dune Chronicles, by Frank Herbert
5. A Song Of Ice And Fire Series, by George R. R. Martin - all that's been published so far, anyway...
6. 1984, by George Orwell
7. Fahrenheit 451, by Ray Bradbury
8. The Foundation Trilogy, by Isaac Asimov
9. Brave New World, by Aldous Huxley
10. American Gods, by Neil Gaiman
11. The Princess Bride, by William Goldman
12. The Wheel Of Time Series, by Robert Jordan - I have resisted and will continue to resist.
13. Animal Farm, by George Orwell
14. Neuromancer, by William Gibson
15. Watchmen, by Alan Moore
16. I, Robot, by Isaac Asimov
17. Stranger In A Strange Land, by Robert Heinlein
18. The Kingkiller Chronicles, by Patrick Rothfuss
19. Slaughterhouse-Five, by Kurt Vonnegut
20. Frankenstein, by Mary Shelley
21. Do Androids Dream Of Electric Sheep?, by Philip K. Dick
22. The Handmaid's Tale, by Margaret Atwood
23. The Dark Tower Series, by Stephen King
24. 2001: A Space Odyssey, by Arthur C. Clarke
25. The Stand, by Stephen King - Hm, shouldn't this be horror?
26. Snow Crash, by Neal Stephenson
27. The Martian Chronicles, by Ray Bradbury
28. Cat's Cradle, by Kurt Vonnegut
29. The Sandman Series, by Neil Gaiman
30. A Clockwork Orange, by Anthony Burgess
31. Starship Troopers, by Robert Heinlein
32. Watership Down, by Richard Adams
33. Dragonflight, by Anne McCaffrey - I have never managed to finish a Pern book. I've read other McCaffery, but Pern has just never worked for me. No idea why.
34. The Moon Is A Harsh Mistress, by Robert Heinlein -- I think??? I've read other Heinlein in this universe, but I honestly can't remember if this was one of them
35. A Canticle For Leibowitz, by Walter M. Miller
36. The Time Machine, by H.G. Wells
37. 20,000 Leagues Under The Sea, by Jules Verne
38. Flowers For Algernon, by Daniel Keys
39. The War Of The Worlds, by H.G. Wells
40. The Chronicles Of Amber, by Roger Zelazny - an all-time favorite.
41. The Belgariad, by David Eddings
42. The Mists Of Avalon, by Marion Zimmer Bradley
43. The Mistborn Series, by Brandon Sanderson
44. Ringworld, by Larry Niven
45. The Left Hand Of Darkness, by Ursula K. LeGuin
46. The Silmarillion, by J.R.R. Tolkien
47. The Once And Future King, by T.H. White
48. Neverwhere, by Neil Gaiman
49. Childhood's End, by Arthur C. Clarke
50. Contact, by Carl Sagan
51. The Hyperion Cantos, by Dan Simmons - loved the first two books, couldn't finish the third
52. Stardust, by Neil Gaiman
53. Cryptonomicon, by Neal Stephenson
54. World War Z, by Max Brooks
55. The Last Unicorn, by Peter S. Beagle
56. The Forever War, by Joe Haldeman
57. Small Gods, by Terry Pratchett
58. The Chronicles Of Thomas Covenant, The Unbeliever, by Stephen R. Donaldson - I HATED THIS BOOK. Fire of a thousand burning suns hated. I'm so glad I didn't feel compelled to move on with the series because from all I hear it only gets worse.
59. The Vorkosigan Saga, by Lois McMaster Bujold
60. Going Postal, by Terry Pratchett
61. The Mote In God's Eye, by Larry Niven & Jerry Pournelle
62. The Sword Of Truth, by Terry Goodkind - Another series I happily gave up on after the first book.
63. The Road, by Cormac McCarthy
64. Jonathan Strange & Mr Norrell, by Susanna Clarke
65. I Am Legend, by Richard Matheson
66. The Riftwar Saga, by Raymond E. Feist
67. The Shannara Trilogy, by Terry Brooks
68. The Conan The Barbarian Series, by R.E. Howard
69. The Farseer Trilogy, by Robin Hobb I read a short story set in this universe and really liked it. Then Robin Hobb made an ass out of herself over fanfiction. I've been on the fence ever since. Anyone want to convince me either way?
70. The Time Traveler's Wife, by Audrey Niffenegger
71. The Way Of Kings, by Brandon Sanderson
72. A Journey To The Center Of The Earth, by Jules Verne
73. The Legend Of Drizzt Series, by R.A. Salvatore
74. Old Man's War, by John Scalzi
75. The Diamond Age, by Neil Stephenson - This is my favorite Stephenson, I wish it were higher on the list.
76. Rendezvous With Rama, by Arthur C. Clarke
77. The Kushiel's Legacy Series, by Jacqueline Carey - unless it's including the third trilogy, in which case this should be underlined; I've only read the first book of that one.
78. The Dispossessed, by Ursula K. LeGuin
79. Something Wicked This Way Comes, by Ray Bradbury - had to read it for English class in 8th grade. Really, really disliked it. I've been a little sour on Bradbury ever since, though I did like Martian Chronicles well enough.
80. Wicked, by Gregory Maguire
81. The Malazan Book Of The Fallen Series, by Steven Erikson
82. The Eyre Affair, by Jasper Fforde
83. The Culture Series, by Iain M. Banks
84. The Crystal Cave, by Mary Stewart
85. Anathem, by Neal Stephenson - this has been on my bedside table as my "to read next" book for at least a year. Other things just keep jumping the line. But I am determined to get to it eventually.
86. The Codex Alera Series, by Jim Butcher
87. The Book Of The New Sun, by Gene Wolfe
88. The Thrawn Trilogy, by Timothy Zahn
89. The Outlander Series, by Diana Gabaldan - as with GRRM, all that is so far published. I'm growing kind of disenchanted with it, though.
90. The Elric Saga, by Michael Moorcock
91. The Illustrated Man, by Ray Bradbury
92. Sunshine, by Robin McKinley - Hearts, hearts, hearts
93. A Fire Upon The Deep, by Vernor Vinge - I really recommend this one, too.
94. The Caves Of Steel, by Isaac Asimov
95. The Mars Trilogy, by Kim Stanley Robinson
96. Lucifer's Hammer, by Larry Niven & Jerry Pournelle
97. Doomsday Book, by Connie Willis
98. Perdido Street Station, by China Mieville
99. The Xanth Series, by Piers Anthony - I read the first six, or maybe it was nine? Probably should have given up a lot sooner.
100. The Space Trilogy, by C.S. Lewis
This entry is also posted at http://owlmoose.dreamwidth.org/544363.html. There are currently comments on DW.